In 1923, St. Anne Parish was established in Lancaster city at the corner of Duke and Liberty Streets. St. Anne School opened  in September of the following year on the second floor of the convent with 72 students and three Sisters of Mercy teaching the children. Over the years, the school and parish continued to grow and additional buildings were added. But by the late 1960's, it was apparent that the church was not large enough for the growing parish, and there was no additional space available to build. A search for property suitable for a new church began.

In the 1970's, a site for the new church was located and a campaign was conducted to build a new church. It was determined by the diocese that given the expanding growth in Manheim Township, the new church would actually become a new parish. In 1978, St. John Neumann Church was founded, new parish boundaries were drawn and St. Anne School became the parish school for both St. Anne and St. John Neumann Parishes.

By the early 2000’s, prompted by the increasing number of  students at St. Anne School who were parishioners at St. John Neumann and the growing population in Manheim Township,  discussions began to move the school to the SJN campus. After several fundraising efforts and attempts to relocate, a final capital campaign reached its funding goal and designs were created to build a new parish school. The official groundbreaking for the new St. John Neumann Catholic School was held on February 2, 2020. Faculty, staff, students and alumni worked over the summer to sort and pack all of the contents of St. Anne School (desks, chairs, supplies, & library books) for their transport four miles up Oregon Pike to the new home of St. Anne School albeit with a new name.
 
 On September 8, 2020, after a blessing by Father Daniel Powell, Pastor, St. John Neumann Catholic School opened for its first day of classes.